缩氨基硫脲类是近年来国外在筛选过程中发现的具有较好疗效和较新结构的抗癌药物.其中以5—羟基吡啶—2—甲醛缩氨基硫脲(5—HP)为最好,已进入白血病治疗的临床试验阶段,其作用机制是与体内的铁离子螯合而抑制核糖核酸还原酶,从而阻断了DNA 的合成.该类药物的今后动向值得注意,为此我们于1973年合成了5—HP 并由 Thiosemicarbazone is an anticancer drug with good curative effect and relatively new structure found in foreign countries in recent years, of which 5-hydroxypyridine-2-carboxaldehyde thiosemicarbazone (5-HP) is the best , Has entered the clinical trial phase of leukemia treatment, its mechanism of action is to chelate with iron ions in the body and inhibit ribonucleic acid reductase, thus blocking the DNA synthesis. The future trend of these drugs is worth noting, for which we in 1973 The year synthesized 5-HP and by