急性心肌梗塞(AMI)的主要原因是在冠脉粥样硬化甚或无明显粥样病变的部位形成了阻塞性血栓,这已为近年来广泛开展的冠脉旁路术、冠脉造影术及冠脉内溶栓疗法所证实。1959年 Fletcher 等首先采用溶栓制剂静注治疗 AMI;1960年 Boyles 等证实冠脉内使用链激酶与纤溶酶混合物可迅速溶解实验性犬冠脉血栓。但直至1979年 Rentrop等采用冠脉内溶栓治疗 AMI 取得显著疗效后,才引起广泛的重视。大量研究证明溶栓 The main cause of acute myocardial infarction (AMI) is the formation of obstructive thrombus at the site of coronary atherosclerosis or even no significant atherosclerosis, which has been widely carried out in recent years, coronary artery bypass grafting, coronary angiography and the crown Intravenous thrombolytic therapy confirmed. In 1959, Fletcher et al. First used intravenous thrombolytic therapy for AMI. In 1960, Boyles et al. Demonstrated that intracoronary streptokinase and plasmin mixture can rapidly dissolve experimental canine coronary artery thrombosis. However, until 1979, Rentrop and other coronary thrombolysis in the treatment of AMI achieved significant results, it attracted widespread attention. A large number of studies have shown that thrombolysis