医院感染病原菌的变迁及耐药菌株的快速变化与抗生素特别是新型广谱抗生素的广泛使用是分不开的。因此,了解和掌握医院感染的流行菌株及其耐药性,是医院感染监测的主要手段。我们对1998、1999年的医院感染细菌及其耐药性的监测情况报道如下。 Changes in nosocomial infections and rapid changes in resistant strains are inseparable from the widespread use of antibiotics, especially novel broad-spectrum antibiotics. Therefore, understanding and mastering the epidemic strains of nosocomial infection and their drug resistance are the main methods for monitoring nosocomial infections. Our reports on the surveillance of nosocomial infections and their drug resistance in 1998 and 1999 are as follows.