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面对丙型肝炎的流行,至今缺少理想的治疗药物和方案,丙型肝炎病毒(HCV)的非结构蛋白3(NS3)蛋白酶是近年来抗丙型肝炎药物研究的重要靶点。作者综述了NS3蛋白酶抑制剂的作用机制和活性特点。
In the face of the epidemic of hepatitis C, so far no ideal therapeutic drugs and programs, hepatitis C virus (HCV) non-structural protein 3 (NS3) protease is an important target of anti-hepatitis C drug research in recent years. The authors review the mechanism of action and activity characteristics of NS3 protease inhibitors.