自1960年Berson和Yalow发明放射免疫测定法以来,此类技术的应用极为广泛,发展极为迅速。有人推测,凡是一切具有活性的生物物质均可用此种方法测定。其应用范围已遍及许多基础与临床的重要学科领域,如内分泌学、生化学、肿瘤学、传染病学、针麻机理等。 由于反应过程中所使用的特异性结合剂的不同,方法上的差异,曾用不同的名称和类型(表1)。 Since the discovery of radioimmunoassay by Berson and Yalow in 1960, the use of such technologies has been extremely broad and rapidly evolving. Some speculated that all active biological substances can be measured by this method. Its scope of application has covered many important basic and clinical disciplines, such as endocrinology, biochemistry, oncology, epidemiology, acupuncture and other mechanisms. Due to differences in the specific binding agents used during the reaction, the methodological differences have been distinguished by different names and types (Table 1).