目的评价食管癌切除术行食管胃单层宽边连续吻合的临床效果。方法将符合手术条件的936例食管癌患者随机分为试验组和对照组,每组468例,均行手术治疗,试验组行食管胃单层宽边连续吻合,对照组行食管胃丝线间断缝合。结果试验组无手术死亡,术后发生吻合口瘘1例(0.2%),吻合口狭窄1例(0.2%),其他并发症17例。对照组围手术期死亡1例,术后发生吻合口瘘8例(1.9%),吻合口狭窄11例(2.4%),其他并发症24例。两组间术后吻合口瘘、吻合口狭窄发生率差异有统计学意义(P值分别为0.019和0.004),而其他并发症的发生率差异无统计学意义(P=0.264)。结论食管胃单层宽边连续吻合方法简便,可有效预防食管胃吻合口瘘和吻合口狭窄的发生。 Objective To evaluate the clinical effect of continuous esophageal and gastric mucosal wide-brimmed continuous esophageal resection. Methods A total of 936 patients with esophageal cancer who underwent surgery were randomly divided into experimental group and control group, with 468 cases in each group. All patients underwent surgical treatment. The esophageal and gastric mucosal wide-brimmed continuous anastomosis in control group, . Results There was no operative death in the experimental group. One case (0.2%) had anastomotic fistula, one case had anastomotic stenosis (0.2%) and 17 cases had other complications. In the control group, 1 patient died during perioperative period, 8 patients (1.9%) had anastomotic leakage, 11 patients (2.4%) had anastomotic stenosis, and 24 patients had other complications. The incidence of anastomotic fistula and anastomotic stricture between the two groups was statistically significant (P = 0.019 and 0.004 respectively), while the incidence of other complications was not statistically different (P = 0.264). Conclusions Esophageal and gastric monolayer wide-brimmed continuous anastomosis method is simple and can effectively prevent the occurrence of esophagogastric anastomotic fistula and anastomotic stenosis.