论文部分内容阅读
肝细胞核因子(Hepatocyte nuclear factors,HNFs)是一类分布在肝、胰、肠、肾等多个组织器官,调节肝脏内基因特异性表达的一类转录因子。其主要亚型为HNF1、HNF3、HNF4和HNF6等,这些转录因子相互作用构成的复杂调控网络。2型糖尿病(Type2 diabetes mellitus,T2DM)的基本病理生理机制是胰岛素抵抗及胰岛β细胞损伤,最终导致高血糖。近年来的研究表明,HNFs在胰岛素抵抗及胰岛β细胞损伤中发挥关键的调控作用。本文对HNFs在T2DM发生中的胰岛素抵抗及胰岛β细胞损伤作用研究新进展作以回顾性综述,旨在为认识T2DM发病机制及提出防治策略提供理论基础。
Hepatocyte nuclear factors (HNFs) are a type of transcription factor that regulates gene-specific expression in the liver in many tissues and organs such as liver, pancreas, intestine and kidney. Its main subtypes are HNF1, HNF3, HNF4 and HNF6, etc. These transcription factors interact to form a complex regulatory network. The basic pathophysiological mechanism of type 2 diabetes mellitus (T2DM) is insulin resistance and islet β cell injury, which eventually leads to hyperglycemia. Recent studies have shown that HNFs play a key regulatory role in insulin resistance and islet β cell injury. This article reviews the recent progress of HNFs on insulin resistance and islet β cell injury in T2DM and provides a theoretical basis for understanding the pathogenesis of T2DM and proposing prevention and treatment strategies.