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OBJECTIVE:To assess the curative effect of Traditional Chinese Medicine (TCM) on leukopenia induced by chemo-radiotherapy in patients with lung cancer.METHODS:A comprehensive electronic search in Medline,Embase,the Cochrane Libary database,China National Knowledge Infrastructure Database (CNKI) and Wanfang Database was conducted up to July 2017.Random-effects model was used to estimate the standardized mean differences (SMDs)with 95% confidence intervals (CIs).Eleven studies with a total of 957 patients were included in this meta-analysis.RESULTS:The effectiveness in TCM group was higher than control group [RR =1.60,95% CI (1.38,1.85),P < 0.000 01].Compare with West Medicine group,the effectiveness has no significant difference [RR =0.96,95% CI (0.82,1.12),P =0.57].The ineffective rate in test group was lower than the control group [RR =0.30,95% CI (0.21,0.42),P < 0.00001].CONCLUSION:By meta-regression it was suggested that TCM has curative effect on leukopenia induced by chemo-radiotherapy in patients with lung cancer,but by the influence of number and quality of researches,publication bias,more evidence from high quality studies,and larger cohorts for observational trials are needed.