在我国,乳腺癌已成为女性中最常见的恶性肿瘤且发病率增长迅速。原发性乳腺癌的治疗包括手术放疗等局部治疗,以及化疗、内分泌治疗,生物治疗等辅助综合治疗。临床指南是基于科学证据,同时对特定临床状况下的病人提出最佳治疗建议欧洲肿瘤内科学会(ESMO)《原发性乳腺癌诊断、治疗及随访指南》是惟一针对原发乳腺癌的临床指南。原发乳腺癌的分子检测与分子靶向治疗是该指南2015年更新的核心内容。 In our country, breast cancer has become the most common malignant tumor in women and the incidence is rapidly increasing. The treatment of primary breast cancer, including local treatment such as surgical radiotherapy, and chemotherapy, endocrine therapy, biological therapy and other complementary comprehensive treatment. Clinical guidelines are based on scientific evidence and suggest the best treatment for patients under specific clinical conditions. The European Society of Oncology (ESMO) Guide to the Diagnosis, Treatment and Follow-up of Primary Breast Cancer is the only clinical guideline for primary breast cancer . Molecular detection and molecular targeted therapies for primary breast cancer are at the core of the 2015 update.