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目的研究鬼臼毒素醇质体经皮渗透特性。方法通过体外经皮渗透试验,比较鬼臼毒素在大鼠皮肤中的稳态透皮速率和皮肤滞留量,分别考察以醇质体、酊剂、脂质体、30%乙醇混悬液以及鬼臼毒素与空白醇质体物理混合物作为载体,鬼臼毒素经皮渗透特性。结果鬼臼毒素醇质体的12 h皮肤滞留量为8.17μg/cm2,高于其他各组;稳态透皮速率小于鬼臼毒素载药量为0.5%的脂质体组及乙醇混悬液组(P<0.05),与其他对照组无显著差异。结论醇质体具有较大的皮肤滞留量及较小的透皮速率。
Objective To study the percutaneous permeability of podophyllotoxin. Methods The transdermal rate and the retention of podophyllotoxin in rat skin were compared by transdermal penetration test in vitro. The effects of podophyllotoxin, tincture, liposome, 30% ethanol suspension and podophyllotoxin The physical mixture of toxin and blank aloe bodies served as a carrier for transdermal penetration of podophyllotoxin. Results The retention of podophyllotoxin in 12 h was 8.17 μg / cm2, higher than that in other groups. The steady-state transdermal rate was less than that of liposomes containing 0.5% podophyllotoxin and ethanol suspension Group (P <0.05), no significant difference with other control groups. CONCLUSIONS Ethosomes have greater skin retention and less transdermal rate.