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选用季铵盐作为抗菌剂,对纳米SiO2颗粒进行表面改性。对合成的季铵盐进行了FT-IR表征。通过FTIR、接触角、Zeta电位等手段研究了烷基链长度及纳米颗粒尺寸对改性纳米SiO2性能的影响,考察了改性纳米SiO2颗粒的抗菌性能。结果表明季铵盐接枝纳米SiO2颗粒表面带正电,随着烷基链的增长,疏水性渐强。抗菌测试表明,改性后的纳米SiO2对金黄色葡萄球菌有很好的抗菌性,24h可以全部杀死浓度为1.72×106 CFU/mL的金黄色葡萄球菌。
Quaternary ammonium salt is chosen as antibacterial agent to modify the surface of nano-SiO2 particles. The synthesized quaternary ammonium salt was characterized by FT-IR. The effects of alkyl chain length and nanoparticle size on the properties of modified nano-SiO2 were investigated by means of FTIR, contact angle and Zeta potential, and the antibacterial properties of the modified nano-SiO2 particles were investigated. The results showed that the surface of quaternary ammonium salt grafted nano-SiO2 particles are positively charged, and the hydrophobicity increases as the alkyl chain grows. Antibacterial tests showed that the modified nano-SiO2 has a good antibacterial activity against Staphylococcus aureus, and can completely kill Staphylococcus aureus at a concentration of 1.72 × 106 CFU / mL at 24h.