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5例机械通气和6例自主呼吸肺心病患者接受了 Almitrine 对心肺功能影响的研究。结果表明,服用150mg Almitrine 后,两组患者的气体交换均明显改善。动脉血氧分压升高、分流减少,自主呼吸患者还伴有动脉血二氧化碳分压明显降低,但同时伴有肺动脉压力升高和肺血管阻力增加,其中,自主呼吸患者的改变最明显。虽然机械通气患者肺动脉压升高的幅度较自主呼吸患者的小,但动静脉血氧含量差明显增加,而且5例中4例有混合静脉血氧分压降低,提示组织供氧受到了影响。
Five patients with mechanical ventilation and six patients with spontaneous respiratory disease accepted Almitrine’s influence on cardiorespiratory function. The results showed that after taking 150mg Almitrine, the gas exchange in both groups was significantly improved. Arterial partial pressure of oxygen increased shunt decreased spontaneous breathing patients accompanied by arterial carbon dioxide partial pressure was significantly lower, but accompanied by increased pulmonary artery pressure and pulmonary vascular resistance increased, of which the most obvious changes in patients with spontaneous breathing. Although the magnitude of pulmonary arterial pressure elevation in patients with mechanical ventilation was smaller than those in spontaneous breathing patients, the difference in arterial oxygenation was significantly increased. In 4 of 5 patients, there was a decrease in mixed venous partial pressure of oxygen, suggesting that tissue oxygen supply was affected.