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目的探讨赠卵体外受精-胚胎移植患者的妊娠结局和疗效。方法选取该院2012年1月-2014年12月期间收治的202例赠卵体外受精-胚胎移植的患者共269个移植周期进行分析,供卵者均采用常规长方案促排卵方法促排卵,受卵者采用激素替代方法准备内膜或自然周期治疗,对受卵患者的妊娠结局进行统计分析。结果 102例患者共114个周期临床妊娠成功,周期妊娠率42.38%(114/269),临床累积妊娠率56.44%(114/202);非条件多因素逐步Logistic回归分析显示,戊酸雌二醇使用及ET胚胎个数均是影响妊娠成功的独立预测因子。结论卵子赠送技术是治疗卵巢功能减退、卵巢早衰、染色体异常等不孕患者的有效方法,激素替代周期可以获得更好的妊娠结局。
Objective To investigate the pregnancy outcome and efficacy of egg-fertilization-embryo transfer (ET-ET) patients. Methods Totally 269 transplant cycles of 202 egg-free in vitro fertilization-embryo transfer patients from January 2012 to December 2014 in our hospital were selected for analysis. Ovaries were given ovulation induction by conventional long-term ovulation induction Eggs were treated with endothelin or natural cycles by hormone replacement, and the pregnancy outcome of the affected patients was statistically analyzed. Results The clinical pregnancy was successful in 102 cycles of 114 cycles, with 42.38% (114/269) cycles of pregnancy and 56.44% (114/202) of clinical pregnancy rates. Logistic regression analysis of unconditional multivariate logistic regression showed that estradiol valerate Both the number of ET embryos used and the number of ETs were independent predictors of pregnancy success. Conclusion Egg donation technique is an effective method for the treatment of infertility patients with ovarian dysfunction, premature ovarian failure and chromosomal abnormalities. The hormone replacement cycle can achieve better pregnancy outcomes.