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目的 探讨β－连接蛋白的表达与大肠腺癌的分化程度、局部侵袭深度、淋巴结转移和Ｄｕｋｅｓ＇分期的关系。 方法 用ＳＰ免疫组化方法检测β－连接蛋白的表达。 结果 ６７．２％ （３９／５８）大肠腺癌β－连接蛋白表达减低，表达减低与癌的分化程度呈正相关（Ｐ＜ ０．０１），与局部侵袭深度、淋巴结转移和Ｄｕｋｅｓ＇分期无关（Ｐ＞ ０．０５）。 结论 大肠腺癌中β－连接蛋白表达常减低，但在癌的侵袭和转移中可能不起重要作用。
Objective To investigate the relationship between the expression of β-catenin and the differentiation of colorectal adenocarcinoma, depth of invasion, lymph node metastasis and Dukes’ staging. Methods SP immunohistochemistry was used to detect the expression of β-catenin. Results The expression of β-catenin in colorectal adenocarcinoma was reduced in 67.2% (39/58) of colorectal adenocarcinomas. The decreased expression was positively correlated with the degree of cancer differentiation (P<0.01). It was not associated with local invasion depth, lymph node metastasis, and Dukes’ stage ( P> 0.05). Conclusion The expression of β-catenin in colorectal adenocarcinoma often decreases, but it may not play an important role in the invasion and metastasis of cancer.