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目的探索Ⅰ期肺鳞癌淋巴结微转移的临床意义。方法应用免疫组化ＬＳＡＢ法对３０例Ⅰ期肺鳞癌ＨＥ阴性的２４８淋巴结作了抗角蛋白抗体（Ｋｅｒ）检测。结果测定的淋巴结中有１０／２４８只阳性，占４％。小巢转移癌细胞位于淋巴结被膜、窦索及脉管内。阳性病例数有８／３０例；占２６７％，其中高分化及中分化鳞癌各４例。随访资料显示，Ｋｅｒ淋巴结阳性与阴性患者之位生存期比较Ｐ＜００５，有显著差异。结论Ⅰ期肺鳞癌的淋巴结中Ｋｅｒ阳性证实有微转移者，对临床分期、治疗及预后均有明显的影响。
Objective To explore the clinical significance of lymph node micrometastasis in stage I squamous cell carcinoma. Methods Immunohistochemical LSAB method was used to detect anti-keratin antibody (Ker) in 30 cases of stage I lung squamous cell carcinoma HE-negative 248 lymph nodes. Results 10/248 lymph nodes were positive, accounting for 4%. Small nest metastasis cancer cells are located in the lymph node capsule, sinus tarsi, and vasculature. The number of positive cases was 8/30; accounting for 26.7%, of which 4 cases were well differentiated and moderately differentiated. Follow-up data showed that the survival time of the patients with positive and negative Ker lymph nodes was P<005, which was significantly different. Conclusion Ker-positive lymph nodes in stage I squamous cell carcinoma are confirmed to have micrometastases, and have significant effects on clinical stage, treatment and prognosis.