以国标GB601-2002为依据,改进了减量法的称样模式,验证了三羟甲基氨基甲烷(THAM)替代国标基准物碳酸钠的可行性和优越性,同时用滴定仪代替手工滴定,用电位突跃替代指示剂判断终点,摸索了自动电位滴定法标定酸标准溶液的适宜控制参数。试验表明,用THAM和Na_2CO_3作基准试剂,分别以自动电位滴定法与国标手工滴定指示剂法标定酸标准溶液的结果均具有较好的一致性。 Based on the national standard GB601-2002, we improved the weighing method, and verified the feasibility and superiority of THAM to replace the national standard sodium carbonate. At the same time, titration was used instead of manual titration, The method of potentiometric titration was used to replace the indicator to determine the end point, and the suitable control parameters for the calibration of acid standard solution by automatic potentiometric titration were explored. Tests showed that the THAM and Na_2CO_3 as a reference reagent, respectively, with the automatic potentiometric titration with the national standard manual titration acid standard solution results are in good agreement.