论文部分内容阅读
目的 :研究新辅助化疗对局部晚期乳腺癌的效果。方法 :收集 1995年 8月— 1998年 11月间行手术治疗的乳腺癌病例 2 18例中 40例局部晚期乳腺癌 ,随机给予CMF(CTX +MTX + 5 FU)方案及ADM +VDS +CTX方案治疗各 2 0例。结果 :在ADM +VDS +CTX联合方案中 ,原发灶有效率 6 0 % (12 / 2 0 ) ,腋窝淋巴结有效率 6 0 % (12 / 2 0 ) ;在CMF方案中 ,原发灶有效率 2 0 % (4 / 2 0 ) ,腋窝淋巴结有效率 30 % (6 / 2 0 )。ADM +VDS +CTX联合化疗方案优于CMF方案 ,尤其在原发灶缩小上有显著差异 (P <0 0 1)。结论 :新辅助化疗可使肿瘤及腋窝淋巴结明显缩小 ,给手术创造有利条件。本研究只限临床近期疗效观察 ,是否可以提高远期疗效 ,尚有待进一步随访观察
Objective: To study the effect of neoadjuvant chemotherapy on locally advanced breast cancer. METHODS: Forty breast cancer cases surgically treated between August 1995 and November 1998 were collected. Forty cases of locally advanced breast cancer in 18 cases were randomly assigned to CMF (CTX + MTX + 5 FU) and ADM + VDS + CTX Treatment of 20 cases each. Results: In the combination of ADM + VDS + CTX, the effective rate of primary tumor was 60% (12/20) and the effective rate of axillary lymph nodes was 60% (12/20). In the CMF regimen, the primary tumor was Efficiency 20% (4/20), axillary lymph node efficiency 30% (6/20). ADM + VDS + CTX combination chemotherapy was superior to CMF, especially in the reduction of primary lesions (P <0.01). Conclusion: Neoadjuvant chemotherapy can significantly reduce the tumor and axillary lymph nodes, creating favorable conditions for surgery. This study only clinical observation of short-term efficacy, whether it can improve long-term efficacy, remains to be further follow-up observation