胃泌素(Gastrin GAS)与颅脑损伤的伤情及预后相关,且并发Cushing溃疡患者血清中的含量显著升高。植物神经功能失调和G细胞的抑制因素减弱是高GAS血症的原因。在重型颅脑损伤初期,GAS参与了Cushing溃疡的发生和发展,后期又参与胃粘膜的修复。及早应用抗酸药物和胃粘膜保护剂能有效预防和治疗Cushing溃疡。善得定(Octreotide)的应用可能会成为药物治疗Cushing溃疡的新方向。 Gastrin GAS is associated with the injury and prognosis of craniocerebral injury, and the serum levels of patients with Cushing ulcer are significantly increased. Decreased autonomic dysfunction and G-cell suppressive factors are responsible for high GAS hyperlipidemia. In the early stage of severe craniocerebral injury, GAS is involved in the occurrence and development of Cushing ulcers, and later in gastric mucosa repair. The early application of antacids and gastric mucosal protective agent can effectively prevent and treat Cushing ulcer. The use of Octreotide may be the new direction for drug treatment of Cushing ulcers.