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目的观察孕妇妊娠中期血清叶酸水平变化,为孕妇补充叶酸提供依据。方法将1038例妊娠中期孕妇按照孕周分为孕12~20周组和孕21~28周组,用电化学发光免疫法检测血清叶酸水平变化。结果随着妊娠周数增加,血清叶酸水平逐渐下降,两组相比差异有统计学意义(P<0.05)。结论妊娠中期后只通过膳食补充叶酸是不够的,还需要补充含叶酸的维生素类补给品,维持血清叶酸的正常值。
Objective To observe the change of serum folic acid level in the second trimester of pregnant women and provide the basis for the supplement of folic acid in pregnant women. Methods 1038 pregnant women in the second trimester were divided into two groups according to gestational age, 12 to 20 weeks pregnant and 21 to 28 weeks pregnant. The changes of serum folic acid levels were detected by electrochemiluminescence immunoassay. Results As the number of weeks of pregnancy increased, the level of serum folate decreased gradually. There was significant difference between the two groups (P <0.05). Conclusions After the second trimester of pregnancy, supplementation of folic acid alone is not enough. Supplements of folic acid-containing vitamin supplements are needed to maintain normal serum folic acid levels.