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目的研究幼年小型猪垂体不同单次剂量照射的放射反应。方法用依附于直线加速器的立体定向放射系统对小型猪垂体一次施照,40周后活杀,对垂体和靶腺器官行组织学检查。结果照射后睾丸间质细胞含量及细胞分泌功能明显下降,且与剂量相关;甲状腺病检见10Gy组增生,15Gy以上组则不同程度退变;光镜观察未见肾上腺及垂体明显改变。结论垂体腺组织单次20Gy的剂量照射后无光镜下结构改变;垂体激素分泌细胞有不同的放射敏感性。
Objective To study the radiation effects of different single doses of pituitary gland in young miniature pigs. Methods The pituitary gland of miniature pigs were administered with a stereotactic radiating system attached to a linear accelerator. The pituitary gland was killed after 40 weeks. Histological examination was performed on the pituitary and target gland organs. Results The content of testicular stromal cells and cell secretory function decreased significantly after irradiation, and were dose-dependent. In thyroid disease, the hyperplasia in 10 Gy group and the degeneration in different groups were observed in 15 Gy group. No significant changes were observed in adrenal gland and pituitary gland. Conclusions The structure of pituitary gland after 20Gy irradiation was changed under light microscope. The pituitary hormone secreting cells have different radiosensitivity.