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为探讨新生儿急性肾功能衰竭 (ARF)血、尿胰岛素样生长因子_Ⅰ (IGF_Ⅰ)的变化及意义 ,采用放射免疫法测定17例对照组新生儿和31例ARF新生儿少尿期、多尿期和恢复期血清和尿IGF_Ⅰ水平。结果显示 ,肾衰组尿IGF_Ⅰ在少尿期和多尿期均显著低于对照组 (P均<0.001) ,恢复期后尿IGF_Ⅰ水平升至正常 ,与少尿期和多尿期比较差异均有显著性 (P<0.001 ,P<0.01) ;肾衰组恢复期尿IGF_Ⅰ与同期尿素氮和血肌酐水平呈显著负相关 (r= -0.425,P<0.05;r= -0.563 ,P<0.01) ;肾衰组血清IGF_Ⅰ显著低于对照组 ,但不同时期的ARF血清IGF_Ⅰ水平无显著变化。提示在新生儿ARF过程中尿IGF_Ⅰ呈先下降后上升变化趋势 ,反映了肾脏的损害及修复过程
To investigate the changes and significance of blood and urine insulin-like growth factor-Ⅰ (IGF-Ⅰ) in neonates with acute renal failure (ARF), the oliguria period of 17 neonates with ARF and 31 ARF neonates were measured by radioimmunoassay Urine and convalescent serum and urine IGF-Ⅰ levels. The results showed that the urinary IGF-Ⅰin renal failure group was significantly lower than that in the control group during oliguria and polyuria (all P <0.001), and the urine IGF-Ⅰlevel increased to normal after convalescence, compared with that in oliguria and polyuria (P <0.001, P <0.01). There was a significant negative correlation between urine IGF-Ⅰ and urine urea nitrogen and serum creatinine in renal failure group (r = -0.425, P <0.05; r = -0.563, P <0.01 ). Serum IGF-I level in renal failure group was significantly lower than that in control group, but there was no significant change in serum IGF-Ⅰ level in ARF at different stages. It is suggested that urinary IGF-Ⅰdecreases first and then changes in neonatal ARF, which reflects the damage and repair process of the kidney