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目的探讨早产儿脑损伤与围生期感染的关系。方法2003年1月至2004年6月沈阳市妇婴医院对49例早产儿行头颅超声检查,根据超声结果,分为脑损伤组(23例)和无脑损伤组(26例)。分别取孕母胎盘做病理学检查并对出生早产儿测血清降钙素原(procalcitonin,PCT)水平作为感染的标志物,观察两组孕母绒毛膜羊膜炎和早产儿感染的发生情况。结果孕母患绒毛膜羊膜炎和有感染的早产儿在脑损伤组分别高达60.86%和78.26%显著高于无脑损伤组的发生率(P<0.01和P<0.05)。结论围生期发生感染的早产儿易发生脑损伤,应加强围生期相关感染指标的监测。
Objective To investigate the relationship between premature infant brain injury and perinatal infection. Methods From January 2003 to June 2004, 49 cases of premature infants underwent ultrasound examination in Shenyang Maternal and Child Hospital. According to the results of ultrasound, they were divided into brain injury group (n = 23) and no brain injury group (n = 26). Pregnant mother’s placenta were taken for pathological examination and serum procalcitonin (PCT) level of preterm newborns was used as a marker of infection. The incidence of pregnant women with chorioamnionitis and premature infants was observed. Results The rates of up to 60.86% and 78.26% of pregnant women with chorioamnionitis and infected preterm infants in brain injury group were significantly higher than those without brain injury group (P <0.01 and P <0.05). Conclusion Premature infants with perinatal infection are prone to brain injury. Perinatal monitoring of infection-related indicators should be strengthened.