许多研究提示牛奶 ,尤其是牛奶中的牛血清白蛋白 (BSA)可能是引起 1型糖尿病的重要饮食因素 ,1型糖尿病易感者的发病和在婴儿期进食牛奶有关。对于 1型糖尿病的动物模型BB大鼠和NOD小鼠 ,在断奶初期给与牛奶或BSA ,可使糖尿病的发病率明显提高。在 1型糖尿病患者血清中可以检测出BSA及其他牛奶蛋白抗体。和BSA抗体结合的自身抗原可能是胰岛B细胞中分子量为 6 90 0 0的蛋白质 Numerous studies have suggested that milk, especially bovine serum albumin (BSA), may be an important dietary contributor to type 1 diabetes. The incidence of type 1 diabetes-related susceptibility is associated with the consumption of milk during infancy. In type 1 diabetic animal models of BB rats and NOD mice, milk or BSA was given early in weaning to significantly increase the incidence of diabetes. BSA and other milk protein antibodies can be detected in patients with type 1 diabetes. An autoantigen that binds to the BSA antibody may be a protein having a molecular weight of 69000 in islet B cells