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The sex-based differences between the effects of two novel sugar-based drug candidates,a sulfated polymannuroguluronate(SPMG-911)and an acidic oligosaccharide sugar chain compound(AOSC-971),on the enzymes CYP 1A2,CYP2E1 and CYP3A4 of Chinese human liver microsome were investigated.The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP3A4,AOSC-971 induced the CYP 2E1 in men but have no effect on CYP1A2,SPMG-911 inhibit the CYP1A2 also in men but have no effect on CYP2E1.The results are useful for their safety evaluation,as well as for the prediction of inter-drug interactions associated with the two drugs.
The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2, CYP2E1 and CYP3A4 of Human liver microsome were investigated.The results showed that neither SPMG-911 nor AOSC-971 had any effect on CYP3A4, AOSC-971 induced the CYP 2E1 in men but no no effect on CYP1A2, SPMG-911 inhibit the CYP1A2 also in men but have no effect on CYP2E1. The results are useful for their safety evaluation, as well as for the prediction of inter-drug interactions associated with the two drugs.