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目的观察疏肝理气填精方治疗乳腺癌术后内分泌治疗所致不良反应的临床疗效。方法将62例乳腺癌术后内分泌治疗出现不良反应的患者随机分为治疗组与对照组,每组31例。对照组予单纯常规内分泌治疗,治疗组在内分泌治疗基础上加用疏肝理气填精方。两组疗程均为2个月,观察比较Kupperman改良评分、子宫内膜厚度、血脂指标及骨密度的变化情况。结果 (1)组间治疗后比较,Kupperman改良评分变化差值治疗组明显高于对照组(P<0.05)。(2)组间治疗后比较,子宫内膜厚度变化差值治疗组明显低于对照组(P<0.05)。(3)组间治疗后比较,三酰甘油水平差异有统计学意义(P<0.05)。(4)组间治疗后比较,治疗组L2-L4、股骨颈BMD水平明显高于对照组(P<0.05)。结论疏肝理气填精方可明显缓解乳腺癌术后内分泌治疗的不良反应,提高患者生活质量,改善预后。
Objective To observe the clinical effects of Shugan Liqi Recipe in treating postoperative adverse reactions induced by endocrine therapy of breast cancer. Methods Sixty-two patients with adverse reactions of endocrine therapy after breast cancer were randomly divided into treatment group and control group, with 31 cases in each group. The control group was treated with simple routine endocrine therapy. The treatment group was treated with Shugan qi filling prescription on the basis of endocrine therapy. The two courses of treatment were 2 months, observed and compared Kupperman improved score, endometrial thickness, blood lipid and bone mineral density changes. Results (1) After treatment, Kupperman improved score difference was significantly higher in the treatment group than in the control group (P <0.05). (2) After treatment, the difference of endometrial thickness difference in treatment group was significantly lower than that in control group (P <0.05). (3) After treatment, the difference of triglyceride level was statistically significant (P <0.05). (4) After treatment, the levels of L2-L4 and femoral neck BMD in the treatment group were significantly higher than those in the control group (P <0.05). Conclusion Shugan Liqi Recipe can significantly relieve the adverse reactions of endocrine therapy after breast cancer, improve the quality of life of patients and improve the prognosis.