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目的探讨胸膜孤立性纤维性肿瘤的临床病理特征。方法选取2011年4月至2014年3月间收治的38例胸膜孤立性纤维性肿瘤患者,收集其临床特征及组织病理学资料,免疫组化检测CD34、波形蛋白(Vimentin)、CD68、CD99、平滑肌肌动蛋白(SMA)、Bcl-2、S100和EMA表达。结果38例胸膜孤立性纤维性肿瘤患者中,CD34、Vimentin、CD99、SMA和Bcl-2均在肿瘤细胞胞质内表达,阳性表达率分别为100.0%、100.0%、65.8%、5.3%和78.9%,CD68、S100、EMA呈阴性。结论胸膜孤立性纤维性肿瘤较少见,组织学形态多样,应注意与其他间叶源性肿瘤相鉴别,可结合其组织学形态及免疫组化染色结果确诊。
Objective To investigate the clinicopathological features of pleural solitary fibrous tumor. Methods Thirty-eight patients with pleural solitary fibrous tumor who were admitted between April 2011 and March 2014 were enrolled. The clinical features and histopathological data were collected. The expression of CD34, vimentin, CD68, CD99, Smooth muscle actin (SMA), Bcl-2, S100 and EMA expression. Results 38 cases of pleural solitary fibrous tumor, CD34, Vimentin, CD99, SMA and Bcl-2 were expressed in the cytoplasm of tumor cells, the positive rates were 100.0%, 100.0%, 65.8%, 5.3% and 78.9 %, CD68, S100, EMA negative. Conclusions Pleural solitary fibrous tumors are rare and histologically diverse. They should be distinguished from other mesenchymal tumors and be diagnosed in combination with their histological features and immunohistochemical staining.