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目的研究并探讨胰腺内分泌肿瘤的病理学特征以及与腺泡细胞癌的鉴别诊断。方法对3例胰腺内分泌肿瘤患者进行临床病理以及免疫组织化学分析,并结合以往研究的结果探讨其与胰腺腺泡细胞癌的鉴别诊断。结果研究结果显示,组织学上胰腺内分泌肿瘤的肿瘤细胞呈现实性片状、小梁状以及腺泡状排列,在结构上与腺泡细胞癌基本相似,但细胞并没有显著异型,细胞间质中血管较为丰富。免疫组织化学表达主要为嗜铬素A以及突触素等。结论胰腺内分泌肿瘤患者多为良性肿瘤,而胰腺腺泡细胞癌则属于高度侵袭性肿瘤,两者虽在形态上较为相似,但生物学行为却完全不同,因此,正确区分两种肿瘤对于临床治疗具有极为重要的意义。
Objective To study and explore the pathological features of pancreatic endocrine tumors and the differential diagnosis of acinar cell carcinoma. Methods Three patients with pancreatic endocrine tumors were studied with clinicopathological and immunohistochemical methods, and combined with the results of previous studies to explore the differential diagnosis of pancreatic acinar cell carcinoma. Results The results showed that the histological pancreatic endocrine tumor cells showed a real flake, trabecular and acinar arrangement, structurally similar to acinar cell carcinoma, but the cells did not significantly shaped, the intercellular substance The blood vessels are more abundant. Immunohistochemical expression of chromogranin A and synaptophysin. Conclusions Pancreas endocrine tumors are mostly benign tumors, while pancreatic acinar cell carcinoma belongs to highly invasive tumors. Although the morphological characteristics of the two groups are similar, their biological behaviors are completely different. Therefore, it is necessary to distinguish the two types of tumors correctly for clinical treatment Has extremely important meaning.