目的　研究细辛、杜仲及其合剂对 D-半乳糖所致衰老小鼠的抗衰老作用。方法　观察小鼠脑组织一氧化氮合酶 (NOS)、血浆一氧化氮 (NO)、全血过氧化氢酶 (CAT)的随龄变化 ,同时观察细辛、杜仲及其合剂对上述指标的影响。结果　老龄小鼠血浆 NO含量 ,脑组织 NOS、全血CAT活性在中年期以前随龄上升 ,中年期以后随龄下降 ;细辛、杜仲及其合剂能够增加 NO含量 ,提高 NOS、CAT活性。结论　细辛、杜仲及其合剂具有一定的抗衰老作用 Objective To study the anti-aging effects of Asarum, Eucommia, and their combinations on aging mice induced by D-galactose. Methods The changes of nitric oxide synthase (NOS), plasma nitric oxide (NO), and whole blood catalase (CAT) in the brain of mice were observed. The effect of Asarum, Eucommia ulmoides Oliv. influences. RESULTS: Plasma NO levels, NOS, and CAT activity in brain tissue of aged mice increased with age before middle age and decreased with age after middle age. Asarum, Eucommia ulmoides Oliv. and its mixture increased NO content and increased NOS, CAT activity. . Conclusion Asarum, Eucommia and their mixtures have certain anti-aging effects