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报道了基于 32通道时间分辨光学层析成像系统的的差分图像重建结果。实验采用两个光学参数与生物组织体大致相同的圆柱型模拟体 ,分别用于模拟新生儿头部和成人手臂。重建结果表明 :采用差分测量的方法很好地重建出了异质体的位置、尺寸及吸收系数相对于背景的变化 ;模拟和实验重建验证了所发展的二维 ,半三维重建算法的可行性 ;使用平均飞行时间作为数据类型、32个探测通道测量 ,比用强度作为数据类型或 16通道测量更为准确地区分出了两个相距 2 0mm的异质体。结果表明用目前的系统可以定性地重建出异质体的位置、尺寸、吸收系数的变化 ,展示该光学层析成像技术将在监测诸如血液含氧量变化、组织体涉氧新陈代谢等生理过程中具有良好应用前景。也对该种成像方法所存在的问题及进一步改进的措施进行了讨论。
The differential image reconstruction based on 32-channel time-resolved optical tomography system is reported. The experiment used two cylindrical simulators with the same optical parameters as the biological tissue, which were used to simulate the neonatal head and adult arm respectively. The reconstructed results show that the location, size and absorption coefficient of the heterogeneous bodies are well reconstructed by the difference measurement method. The simulation and experimental reconstruction verify the feasibility of the developed 2D and 3D reconstruction algorithms ; Using mean time-of-flight as the data type, 32 probing channels measure two 20 mm apart heterogeneous bodies more accurately than using intensity as a data type or 16-channel measurements. The results show that the present system can qualitatively reconstruct the location, size and absorption coefficient of the heterogeneous body. The results show that this optical tomography technique will be useful in monitoring physiological processes such as changes in blood oxygen levels and tissue oxygen metabolism, Has good application prospects. The problems existing in the imaging method and the further improvement measures are also discussed.