目前，力竭运动或运动疲劳状态下线粒体结构及其功能的变化受到了广泛的重视。力竭运动状态下线粒体内膜流动性及呼吸链酶活性发生变化，使氧化磷酸化过程受阻，致使ATP生成减少，影响了运动能力。笔者从自由基学说、电子漏引起质子漏假说及钙反常三方面就力竭运动对线粒体氧化磷酸化偶联程度的一些影响进行阐述，探讨影响线粒体功能的一些机制。 At present, the exhaustive exercise or exercise fatigue mitochondrial structure and function changes have received widespread attention. Under exhaustive exercise, mitochondrial inner membrane fluidity and respiratory chain enzyme activity change, so that the process of oxidative phosphorylation blocked, resulting in decreased ATP production, affecting the exercise capacity. The author expounds some effects of exhaustive exercise on mitochondrial oxidative phosphorylation coupling degree from the theory of free radical, the hypothesis of proton leakage caused by electron leakage and abnormal calcium, and discusses some mechanisms that affect mitochondrial function.