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目的探讨MMP-2、TIMP-2在口腔鳞癌浸润转移中的作用,为口腔鳞癌的治疗及预后判断提供实验依据。方法采用免疫组化SP法检测50例口腔鳞癌组织和10例正常口腔黏膜组织中MMP-2、TIMP-2的表达,分析其表达与临床指标的关系。结果 OSCC中MMP-2的表达显著高于正常口腔黏膜组(P<0.01),其阳性表达率分别为76%和10%,深层浸润的口腔鳞癌组织中,MMP-2的阳性表达率显著高于浅层浸润的口腔鳞癌组织(P<0.05)。TIMP-2在口腔鳞癌组织中的阳性表达率为48%,正常口腔黏膜中TIMP-2的阳性表达率为40%。两者相比,差异无统计学意义(P>0.05)。深层浸润的口腔鳞癌组织中,TIMP-2的阳性表达率显著低于浅层浸润的口腔鳞癌组织(P<0.05)。MMP-2和TIMP-2在口腔鳞癌中的表达有明显的相关性,MMP-2和TIMP-2表达之间的平衡在口腔鳞癌侵袭转移过程中有重要作用。结论 MMP-2、TIMP-2的阳性表达与肿瘤浸润程度密切相关。提示MMP-2有促进肿瘤浸润转移的作用。TIMP-2有抑制肿瘤浸润转移的作用。
Objective To investigate the role of MMP-2 and TIMP-2 in the invasion and metastasis of oral squamous cell carcinoma (OSCC), and to provide experimental evidence for the treatment and prognosis of oral squamous cell carcinoma. Methods Immunohistochemical SP method was used to detect the expression of MMP-2 and TIMP-2 in 50 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa tissues. The relationship between the expression of MMP-2 and TIMP-2 was analyzed. Results The positive expression rate of MMP-2 in OSCC was significantly higher than that in normal oral mucosa (P <0.01), and the positive rate was 76% and 10% respectively. The positive expression rate of MMP-2 in OSCC was significantly higher than that in normal oral mucosa Higher than the shallow infiltration of oral squamous cell carcinoma (P <0.05). The positive expression rate of TIMP-2 in oral squamous cell carcinoma was 48%, and the positive expression rate of TIMP-2 in normal oral mucosa was 40%. There was no significant difference between the two groups (P> 0.05). The positive expression rate of TIMP-2 in deep infiltrating oral squamous cell carcinoma was significantly lower than that in shallow infiltrating oral squamous cell carcinoma (P <0.05). The expression of MMP-2 and TIMP-2 in oral squamous cell carcinoma has obvious correlation. The balance between the expression of MMP-2 and TIMP-2 plays an important role in the invasion and metastasis of oral squamous cell carcinoma. Conclusion The positive expression of MMP-2 and TIMP-2 is closely related to the degree of tumor invasion. Prompt MMP-2 promote tumor invasion and metastasis. TIMP-2 can inhibit tumor invasion and metastasis.