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目的 :探讨在中重度支气管哮喘治疗中应用噻托溴铵的临床疗效。方法 :随机选取我院2012年4月-2014年4月救治的中重度支气管哮喘患者120例,随机分为对照组和观察组,对照组患者依据全球哮喘防治创议GINA方案进行常规治疗办法,观察组患者在对照组基础上每天外加18ug的噻托溴铵,比较两组患者哮喘控制测试评分、用力呼气峰速、吸入支气管扩张剂后一秒钟用力呼气量、每周急救药使用次数、用力呼气中期流速(25%-75%)值等指标。结果 :观察组患者的哮喘控制测试评分、用力呼气峰速、吸入支气管扩张剂后一秒钟用力呼气量、每周急救药使用次数、用力呼气中期流速(25%-75%)值等指标均优于对照组,对比具有统计学意义(p<0.05)。结论 :噻托溴铵结合常规治疗办法在治疗中重度支气管哮喘临床疗效显著,值得推广应用。
Objective: To investigate the clinical efficacy of tiotropium in the treatment of moderate-severe bronchial asthma. Methods: A total of 120 patients with moderate-to-severe bronchial asthma who were treated in our hospital from April 2012 to April 2014 were selected randomly and randomly divided into control group and observation group. Patients in the control group were treated according to the GINA regimen of global asthma prevention and treatment routinely. Group patients in the control group on the basis of daily plus 18ug of tiotropium, asthma control test scores were compared between the two groups, forced expiratory peak speed, inhaled bronchodilator forced exhaled a second, the number of weekly emergency use of drugs , Forced expiratory mid-term flow rate (25% -75%) and other indicators. Results: The asthma control test score, forced expiratory peak velocity, forced expiratory volume one second after inhalation of bronchodilator, the number of emergency medicine used per week, forced expiratory mid-flow rate (25% -75%) And other indicators were better than the control group, the comparison was statistically significant (p <0.05). Conclusion: Tiotropium combined with routine treatment in the treatment of moderate-severe bronchial asthma clinically significant effect, it is worth promoting the application.