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目的探讨液基细胞学(thinprep cell test,TCT)在宫颈癌早期筛查中的价值。方法分析2012年9月—2013年9月2 563例采用TCT进行检查的患者的宫颈细胞涂片资料,并随机选取其中的200例进行阴道镜下活检。观察并计算宫颈TCT结果分布及描述性诊断(the bethesda system,TBS)各类别细胞学阳性结果符合率。结果 2 563例TCT中,正常或炎症、未明确诊断意义的不典型鳞状细胞(atypical squamous cells of undetermined,ASCUS)例数最多,分别占83.26%和13.62%;其中鳞状细胞癌(鳞癌)7例,占0.27%;低度鳞状上皮内病变(lowgrade squamous intraepithelial lesion,LSIL)的细胞学与病理活检符合率为76.32%,高度鳞状上皮内病变(high grade squamous intraepithelial lesion,HSIL)的符合率为81.82%,鳞癌的符合率为100.00%。结论 TCT检查可发现宫颈癌早期病变,及时配合阴道镜活检可提高筛检的符合率。
Objective To investigate the value of thinprep cell test (TCT) in early screening of cervical cancer. Methods Cervical smears of 2 563 patients undergoing TCT from September 2012 to September 2013 were analyzed, and 200 of them were selected for colposcopy biopsy. The distribution of cervical TCT results and the coincidence rate of positive results of cytology in each category of the bethesda system (TBS) were observed and calculated. Results The number of atypical squamous cells of undetermined (ASCUS) cases was 83.26% and 13.62% respectively in 2 563 cases of TCT, which were squamous cell carcinoma (SCC) ) In 7 cases, accounting for 0.27%. The coincidence rate of cytology and pathological biopsy of low grade squamous intraepithelial lesion (LSIL) was 76.32%, high grade squamous intraepithelial lesion (HSIL) The coincidence rate was 81.82% and the coincidence rate of squamous cell carcinoma was 100.00%. Conclusion TCT can detect early lesions of cervical cancer, timely colposcopy biopsy can improve the coincidence rate of screening.