【摘 要】
：
Cell reprogramming is the process of reverting mature,specialized cells into induced pluripotent stem cells.Reprogramming also refers to the erasure and re-establish-ment of epigenetic markers during the development of mammalian germ cells,such as DNA met
【机 构】
：
College of Pharmacy,School of Medicine,and Department of Neurosurgery,The Affiliated Hospital,Hangzh
论文部分内容阅读
Cell reprogramming is the process of reverting mature,specialized cells into induced pluripotent stem cells.Reprogramming also refers to the erasure and re-establish-ment of epigenetic markers during the development of mammalian germ cells,such as DNA methylation [1].At present,reprogramming mainly refers to two processes:the process of reverting differentiated cells to a pluripotent state,and the process of transforming one type of differentiated cell into another [2].Reprogramming mainly includes induced pluripotent stem (iPS) cells,direct trans-differentiation,and indirect lineage conversion.
其他文献
The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main issues attracting the attention of psychiatrists over the last decade.The first part of this review summarizes the pathogenesis of schizo
cFos is one of the most widely-studied genes in the field of neuroscience.Currently,there is no systematic database focusing on cFos in neuroscience.We developed a curated database—cFos-ANAB—a cFos-based web tool for exploring activated neurons and associ
Visual object recognition in humans and nonhu-man primates is achieved by the ventral visual pathway(ventral occipital-temporal cortex,VOTC),which shows a well-documented object domain structure.An on-going question is what type of information is processe
Epilepsy is a brain condition characterized by the recurrence of unprovoked seizures.Recent studies have shown that complement component 3 (C3) aggravate the neuronal injury in epilepsy.And our previous studies revealed that TRPV1 (transient receptor pote
The capacity for neurogenesis in the adult mam-malian brain is extremely limited and highly restricted to a few regions,which greatly hampers neuronal regeneration and functional restoration after neuronal loss caused by injury or disease.Meanwhile,transp
Group 1 metabotropic glutamate receptors(Gp1 mGluRs),comprising mGluRl and mGluR5,are predominantly located at postsynaptic terminals.G1l mGluRs induce the activation of phospholipase C-γ,generate inositol triphosphate and diacylglycerol,and trigger a loc
More than 200 million people across the world suffer from moderate to severe visual impairments,mostly due to retinal degeneration or damage to the eyes[1].Methods of reprogramming the cells in the eyes or electrical stimula-tion can be used to restore vi
Effective methods for visualizing neurovascular morphology are essential for understanding the normal spinal cord and the morphological alterations associated with diseases.However,ideal techniques for simultane-ously imaging neurovascular structure in a
Dear Editor,rnNeuroticism,a crucial dimension of human personality,fluctuates from emotional stability to instability[1].Compared to those with emotional stability,individuals with emotional instability show stronger attentional bias to negative stimuli,l
Acute pain plays an important physiological role as a warning system for the body.However,in many patients,nerve damage leads to neuropathic pain that can last for years and disrupts their quality of life.Unfortunately,neuropathic pain mechanisms remain l