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用麻醉开胸狗研究了冠状动脉前降支急性阻断后1和2小时,分别静注心得安和硝苯吡啶对心肌梗塞范围和血液动力学的影响。结果表明,尽管对照组与给药组之间的左室重量、心肌缺血范围等均相似,但药物未能明显缩小心肌梗塞范围,却使血液动力学发生较大的短暂变化。
Anesthetic thoracotomy dogs were used to study the effects of propranolol and nifedipine on infarct size and hemodynamics at 1 and 2 h after acute anterior descending coronary artery occlusion. The results showed that, although the left ventricular mass and myocardial ischemia between the control group and the administration group were similar, the drug did not significantly reduce the range of myocardial infarction, but the hemodynamics made a larger transient changes.