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我们在固定的人群中对乙肝疫苗免疫后,感染HBV者的抗体情况进行了长期系统的血清学检测和临床学观察。观察对象平均年龄10岁,性别均衡,经血清学检测HBV感染标记全部阴性并无肝炎史者151人。按0、1、2免疫程序常规接种乙肝疫苗10μg/次后,连续4年定期采血,分离血清,用SPRIA法和Ab-bott试剂盒检测HBsAg、抗HBc和抗HBs;用改良赖氏法检验SGPT,并由专职医务人员进行定期临床随访。在经过免疫的儿童群体中,在追踪观察的第2年,140人中检出HBV感染者4例。第2年,在101人中检出1例,累积感染率分别为2.86％和4.95％。在5例感染者中,乙肝疫苗接种后的第6个月,抗-HBs时点高峰值分别为6.1、3.7、7.3、7.8、
We conducted a long-term systematic serological test and clinical observation of the antibody status of patients infected with HBV after the hepatitis B vaccine was immunized in a fixed population. The average age of observers 10 years of age, gender balance, all seroprevalence HBV markers were negative and no history of hepatitis, 151 people. According to 0, 1, 2 immunization routine routine inoculation of hepatitis B vaccine 10μg / times, for 4 consecutive years of regular blood collection, serum separation, SPRIA method and Ab-bott kit detection of HBsAg, anti-HBc and anti-HBs; SGPT, and full-time medical staff for regular clinical follow-up. Of the immunized children, 4 were detected in 140 of 140 HBV-infected persons in the second year of follow-up. The second year, out of 101 people were detected in 1 case, the cumulative infection rates were 2.86% and 4.95%. Among the 5 infected patients, the peak of anti-HBs at the 6th month after hepatitis B vaccination were 6.1, 3.7, 7.3 and 7.8 respectively,