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为探讨纤维组织细胞瘤性脑膜瘤(FHM)的临床病理特征,对11例 FHM 进行临床病理、免疫组化和超微结构观察。结果表明,电镜观察发现瘤细胞有向纤维细胞和组织细胞分化的特征,免疫组化显示波形蛋白、上皮膜抗原、α-抗糜蛋白酶均阳性,胶质纤维酸性蛋白阴性。11例中良性和高度间变各1例,低度恶性9例。结论:FHM 多呈低度恶性,电镜及免疫组化对本病的诊断具有重要意义,手术应尽量切除以防止复发。
To investigate the clinicopathological features of fibrosangiomatous meningioma (FHM), 11 cases of FHM were observed with clinicopathological, immunohistochemical and ultrastructural observation. The results showed that the tumor cells were characterized by the differentiation of fibroblasts and histiocytic cells. Immunohistochemistry showed that vimentin, epithelial membrane antigen, α-chymotrypsin were all positive and glial fibrillary acidic protein was negative. Eleven cases of benign and a high degree of change between the 1 case, 9 cases of low grade. Conclusion: FHM mostly low grade malignant, electron microscopy and immunohistochemistry of the diagnosis of the disease is of great significance, surgery should be removed as far as possible to prevent recurrence.