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HIV感染后对疾病的易感性具遗传限制性,免疫应答的激活在疾病进程中占重要地位.文章提出HIV外壳糖蛋白酷似外源MHC分子从而刺激异体反应淋巴细胞,这种激活可以解释慢性GVHD与AIDS在临床及免疫学方面明显的相似.
The HIV susceptibility to the disease is genetically limited and the activation of the immune response plays an important role in the disease process.The article suggests that the HIV envelope glycoprotein resembles exogenous MHC molecules to stimulate alloreactive lymphocytes and this activation may explain chronic GVHD Clearly similar to AIDS in clinical and immunological aspects.