论文部分内容阅读
观察心肌顿抑后微血管可逆性损伤的超微结构改变，以及钙拮抗剂呋喃丙吡啶对微血管损伤是否具有保护作用．方法：建立兔心肌顿抑模型，采用镧醛灌注固定法制备电镜样品．缺血再灌注前用呋喃丙吡啶预防性给药．结果：闭塞15min再灌注15min时，血管扩张，间隙水肿，血管内外附着大量的镧颗粒．再灌注30min时损伤进一步加重，但血管膜结构完整，直至再灌注120min血管通透性损伤基本恢复正常．预防性给予呋喃丙吡啶后，闭塞15min再灌注15min，血管内皮结构完整，仅在血管腔内有镧颗粒附着在血管壁上，血管外间隙水肿减轻．结论：心肌顿抑时微血管通透性增加，血管内膜结构完整，随着再灌注时间延长，血管通透性恢复正常．缺血再灌注前预先应用呋喃丙吡啶防治可以限制微血管顿抑．
To observe the ultrastructural changes of reversible microvascular injury after myocardial stunning, and whether the calcium antagonist furanopyridine has a protective effect on microvascular injury. Methods: Rabbit myocardial stunning model was established. Electron microscopy samples were prepared by the method of laureth al perfusion fixation. Premedication with furopyr for ischemia and reperfusion. Results: 15min occlusion 15min reperfusion, vasodilation, interstitial edema, large amounts of lanthanum particles attached to the blood vessels inside and outside. The injury was further aggravated 30 min after reperfusion, but the vascular membrane structure was intact, and the vascular permeability injury returned to normal until 120 min after reperfusion. Preventive administration of furanopyridine, occlusion 15min reperfusion 15min, vascular endothelial integrity, only in the vascular cavity lanthanum particles attached to the vessel wall, extravascular space edema reduced. Conclusion: Microvascular permeability increased during myocardial stunning, and the structure of intima was intact. With the prolongation of reperfusion time, vascular permeability returned to normal. Pretreatment with furanopyridine before ischemia / reperfusion can limit microvascular defection.