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金霉素滴眼剂较早的处方是盐酸金霉素0.5克,氯化钠1.25克,硼砂0.5克,蒸溜水加至100毫升。这个处方有一些缺点:(1)保存时间短,一般在室温中最多只能保存48小时,2～4℃也只能保存4天左右;(2)必须临时配制,以免失效。因而操作繁琐,减低了调配工作的效率:(3)金霉素在常温下溶解较慢,时间太短不能充分溶解,为了发给病人而迅速过滤易造成含量损失。近年来有的医疗单位将金霉素滴眼剂的处方进行了一些改进,我们仅就其中一些处方的稳定性进行了研究,兹分述如下:
Aureomycin eye drops earlier prescription 0.5 mg chlortetracycline hydrochloride, 1.25 g sodium chloride, 0.5 g borax, distilled water to 100 ml. The prescription has some disadvantages: (1) The preservation time is short, generally can only be stored at room temperature for up to 48 hours, and can only be stored for about 4 days at 2-4 ° C .; (2) It must be prepared temporarily to avoid failure. Thus cumbersome operation, reducing the efficiency of the deployment of work: (3) chlortetracycline dissolved slowly at room temperature, the time is too short can not be fully dissolved, in order to send to the patient and quickly lead to the loss of content. In recent years, some medical institutions have made some improvements to the prescription of chlortetracycline eye drops. We only study the stability of some of these prescriptions. Here is the breakdown: