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目的观察辅助化疗诱导闭经对乳腺癌患者预后的影响。方法 78例行辅助化疗的乳腺癌患者,将出现诱导闭经现象的46例作为观察组,未出现诱导闭经现象的32例作为对照组。比较两组患者化疗反应、接受化疗时间及无复发生存时间。结果两组各项化疗反应比较,差异均无统计学意义(P>0.05)。观察组接受化疗时间为(3.9±2.9)个月,与对照组的(3.9±3.1)个月比较,差异无统计学意义(P>0.05);观察组无复发生存时间明显长于对照组,差异具有统计学意义(P<0.05)。结论乳腺癌患者辅助化疗出现诱导闭经现象可能提示治疗可取得更理想的预后。
Objective To observe the effect of adjuvant chemotherapy-induced amenorrhea on the prognosis of patients with breast cancer. Methods Totally, 46 patients with induced amenorrhea who underwent adjuvant chemotherapy were selected as the observation group and 32 patients who did not induce amenorrhea as the control group. Chemotherapy response was compared between the two groups, and the duration of chemotherapy and non-recurrence were compared. Results There was no significant difference between the two groups in response to chemotherapy (P> 0.05). The observation group received chemotherapy for (3.9 ± 2.9) months, compared with the control group (3.9 ± 3.1) months, the difference was not statistically significant (P> 0.05); the observation group the recurrence-free survival time was significantly longer than the control group, the difference Statistically significant (P <0.05). Conclusion The induction of amenorrhea by adjuvant chemotherapy in patients with breast cancer may suggest that the treatment can achieve a more satisfactory prognosis.