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目的:比较孢唑啉钠与头孢硫脒用于乳腺癌患者围手术期预防感染的疗效及安全性。方法:抽取2014年8月—2016年3月间收治的行乳腺癌手术患者104例,根据用药方案不同将其分为对照组(n=52)与治疗组(n=52);对照组患者给予头孢硫脒治疗,治疗组患者给予头孢唑啉钠治疗;比较治疗前后两组患者的白细胞计数、中性粒细胞计数及体温变化情况和治疗费用,以及不良反应的发生率。结果:两组患者治疗前后白细胞计数、中性粒细胞及体温测得值经组间比较其差异无统计学意义(P>0.05);治疗期间两组患者均未出现感染及呕吐、恶心等不良反应;住院费用及检查费经组间比较其差异无统计学意义(P>0.05),但治疗组用药费用为(15.87±1.76)元及治疗总费用为(6524.87±961.82)元明显少于对照组(P<0.05)。结论:接受乳腺癌手术治疗患者围手术期给予头孢唑啉钠及头孢硫脒均可有效预防感染的发生,对白细胞计数及体温等影响较小、安全性高;但采用头孢唑啉钠的经济学成本费用更低。
OBJECTIVE: To compare the efficacy and safety of cyprodinil and cefathiamidine in preventing perioperative infection in breast cancer patients. Methods: A total of 104 breast cancer patients who underwent surgery between August 2014 and March 2016 were selected and divided into control group (n = 52) and treatment group (n = 52) according to the drug regimen. Patients in the control group Cefathiamidine was given to the patients in the treatment group, and cefazolin sodium was given to the patients in the treatment group. The white blood cell count, neutrophil count, body temperature, treatment costs, and the incidence of adverse reactions were compared between the two groups before and after treatment. Results: Before and after treatment, the white blood cell count, neutrophil and body temperature measured value between the two groups had no significant difference (P> 0.05). There was no infection, vomiting and nausea in both groups during the treatment (P <0.05). However, the cost of medication and the total cost of treatment in the treatment group were (15.87 ± 1.76) yuan and (6524.87 ± 961.82) yuan respectively, significantly lower than those in the control group Group (P <0.05). CONCLUSION: Cefazolin sodium and cefathiamidine can effectively prevent the occurrence of infection during perioperative period in patients undergoing breast cancer surgery, and have less influence on white blood cell count and body temperature and high safety. However, the use of cefazolin sodium The cost of learning is lower.