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目的:探讨胃肠道间质瘤(GIST)的临床特征及外科治疗。方法:对30例GIST患者的临床表现、诊断、治疗、预后进行回顾性分析。结果:GIST可见于各年龄段,平均年龄(56.3±8.7)岁,男女比例为1:1.14;主要发生部位为胃和小肠(83.3%);临床症状以腹部隐痛不适、腹部肿物和消化道出血为主要表现,无特征性;手术前确诊较为困难,本组资料确诊率只有20.0%;均行手术切除,随访2～60个月,死亡3例,均死于腹腔广泛转移。结论:GIST的诊断依靠免疫组化分析,加强对GIST的认识,规范手术及合理的靶向药物治疗是治疗GIST的关键。
Objective: To investigate the clinical features and surgical treatment of gastrointestinal stromal tumors (GIST). Methods: The clinical manifestations, diagnosis, treatment and prognosis of 30 GIST patients were analyzed retrospectively. Results: GIST was found in all age groups, with an average age of (56.3 ± 8.7) years old, the ratio of male to female was 1: 1.14. The main site of occurrence was stomach and small intestine (83.3%). Clinical symptoms included abdominal pain and discomfort, abdominal mass and digestive tract Bleeding as the main performance, no characteristic; diagnosis is difficult before surgery, the data confirmed in this group was only 20.0%; were underwent surgical resection, followed up for 2 to 60 months, 3 died, all died of widespread abdominal metastasis. Conclusion: The diagnosis of GIST relies on immunohistochemical analysis to enhance the understanding of GIST. Standardized surgery and rational targeted drug therapy are the key to the treatment of GIST.