survivin是近年来发现的一种肿瘤凋亡抑制蛋白,可抑制细胞凋亡、调节细胞周期和促进细胞分裂以及参与血管生成,与化疗药物的耐药性和放疗抵抗有关。其在恶性肿瘤中表达具有高度特异性,几乎所有恶性肿瘤组织都存在高表达,而在正常成人组织中却未表达。survivin已成为具有潜在价值的肿瘤标志物,与肿瘤诊断、治疗和预后相关,有望成为肿瘤治疗的新靶点。本文就survivin的分子生物学结构、肿瘤治疗中的临床意义和survivin相关的肿瘤治疗作一综述。 Survivin is a tumor suppressor protein discovered in recent years. It can inhibit apoptosis, regulate cell cycle, promote cell division and participate in angiogenesis. It is related to chemoresistance and radioresistance. Its expression in malignant tumors is highly specific, almost all malignant tumors are highly expressed, but not expressed in normal adult tissues. Survivin has become a potential tumor marker, which is related to tumor diagnosis, treatment and prognosis, which is expected to become a new target of tumor therapy. This review summarizes the molecular biology of survivin, the clinical significance of tumor therapy, and the treatment of survivin-related tumors.