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近年来,由于对主族元素砷、锑、铋的生物功能研究的不断深入,人们已经从仅仅关注它们对人体的生物毒性到开始研究它们在化学药物领域的应用和潜力。本文简要地介绍了砷、锑、铋作为药物应用的历史,综述了近年来砷、锑、铋的化合物在抗癌、治疗白血病、抗寄生虫病和抗菌方面的一些应用,以及用于发现这些药物的靶分子和结合蛋白的现代生物技术。
In recent years, due to the continuous research into the biological functions of the main elements of arsenic, antimony and bismuth, people have started to study their application and potential in the field of chemical drugs by just paying attention to their biological toxicity to humans. This article briefly introduces the history of the use of arsenic, antimony and bismuth as pharmaceuticals and summarizes some of the applications of arsenic, antimony and bismuth compounds in anticancer, leukemia, antiparasite and antimicrobial activity in recent years, as well as for the discovery of these Modern Biotechnology for Drug Targets and Binding Proteins.