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目的检测高迁移率蛋白A2(HMGA2蛋白在人基底细胞样乳腺癌和非基底细胞样乳腺癌组织中的表达,分析其临床病理学意义。方法应用免疫组织化学方法检测56例基底细胞样乳腺癌和28例非基底细胞样乳腺癌组织中HMGA2蛋白的表达,分析HMGA2表达水平与乳腺癌临床病理特征的相关性。结果 HMGA2在人基底细胞样乳腺癌中的阳性率为92%(51/56),明显高于非基底细胞样乳腺癌组织的阳性率(P<0.05)。HMGA2蛋白表达与基底细胞样乳腺癌的淋巴结有无转移、病理学分级和TNM分期均有相关性。结论基底细胞样乳腺癌存在HMGA2蛋白的高表达。HMGA2基因的表达可能影响基底细胞样乳腺癌的发生、发展。
Objective To detect the expression of HMGA2 protein in human basal-like breast carcinoma and non-basal-like breast carcinoma and to analyze its clinicopathological significance.Methods Immunohistochemistry was used to detect 56 cases of basal-like breast carcinoma And 28 cases of non-basal cell-like breast cancer HMGA2 protein expression, HMGA2 expression levels and clinicopathological features of breast cancer.Results The positive rate of HMGA2 in human basal-like breast cancer was 92% (51/56 ) Was significantly higher than that in non-basal-like breast cancer (P <0.05) .HMGA2 protein expression was correlated with lymph node metastasis, pathological grade and TNM stage in basal-like breast cancer.Conclusion Basal cells HMGA2 protein is highly expressed in breast cancer, and the expression of HMGA2 gene may affect the occurrence and development of basal-like breast cancer.