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目的：研究ｎｍ２３基因表达与前列腺癌生物学行为和预后的关系。方法：应用ＳＰ免疫组织化学染色及微波炉抗原修复方法。结果：ｎｍ２３的表达阳性率为７９．５％；前列腺癌ｎｍ２３低表达者的转移发生率（７５．０％）明显高于高表达者（３０．４％），Ｐ＜０．００５；ｎｍ２３表达水平与前列腺癌的分化程度无相关性（Ｐ＞０．０５），与前列腺癌的临床分期呈负相关（Ｐ＜０．０５）；ｎｍ２３高表达的患者术后３年和５年生存率分别为６０．６％和５１．０％，显著高于ｎｍ２３低表达者（３９．１％和２２．２％），Ｐ＜０．０５和Ｐ＜０．０１。结论：ｎｍ２３基因低表达与前列腺癌的浸润及转移有关，是预后不良的指标。
Objective: To study the relationship between nm23 gene expression and biological behavior and prognosis of prostate cancer. Methods: SP immunohistochemical staining and microwave antigen retrieval method. Results: The positive expression rate of nm23 was 79.5%. The incidence of metastasis of nm23 in prostate cancer was significantly higher than that in high expression (75.4%) (P <0.005) (P> 0.05), but negatively correlated with the clinical staging of prostate cancer (P <0.05). The 3-year and 5-year survival rates of patients with nm23 overexpression were respectively 60.6% and 51.0% respectively, which were significantly higher than those with low expression of nm23 (39.1% and 22.2%, P <0.05 and P <0.01). Conclusion: The low expression of nm23 gene is associated with the invasion and metastasis of prostate cancer, which is an indicator of poor prognosis.