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目的研究CTEN蛋白和E-钙黏蛋白(E-cad)在乳腺浸润性导管癌中的表达及其临床意义。方法采用免疫组化检测80例乳腺浸润性导管癌组织(A组)和25例癌旁乳腺组织(B组)中CTEN和E-cad蛋白的表达量,分析其与临床病理特征及预后的关系。结果 A组CTEN蛋白表达阳性率为68.75%,B组无CTEN蛋白表达;A组E-cad蛋白表达阳性率为58.75%,低于B组的92.00%(P<0.05)。A组CTEN和E-cad蛋白的表达与肿瘤大小、组织学分级、有无淋巴结转移、TNM分期和雌激素受体表达密切相关性(P<0.05);乳腺浸润性导管癌组织中CTEN和E-cad的表达呈负相关(r=-0.346,P<0.05);COX回归分析显示,CTEN表达水平可作为乳腺浸润性导管癌预后判断的独立因素(P<0.05)。结论 CTEN和E-cad蛋白可能在乳腺浸润性导管癌的发生和发展中起重要作用,检测CTEN表达对患者預后的判断具有一定的意义。
Objective To study the expression and clinical significance of CTEN protein and E-cadherin in breast invasive ductal carcinoma. Methods Immunohistochemistry was used to detect the expression of CTEN and E-cad in 80 cases of invasive ductal carcinoma of breast (group A) and 25 cases of adjacent normal breast tissues (group B). The relationship between the expression of CTEN and E-cad was analyzed with the clinicopathological features and prognosis . Results The positive expression rate of CTEN protein in group A was 68.75%, while that in group B was no. The positive expression rate of E-cad protein in group A was 58.75%, which was lower than that in group B (92.00%, P <0.05). The expression of CTEN and E-cad protein in group A was closely related to tumor size, histological grade, lymph node metastasis, TNM stage and estrogen receptor expression (P <0.05); CTEN and E in invasive ductal carcinoma -cad (r = -0.346, P <0.05). COX regression analysis showed that the expression level of CTEN was an independent prognostic factor for breast invasive ductal carcinoma (P <0.05). Conclusion The expressions of CTEN and E-cad may play an important role in the pathogenesis and progression of invasive ductal carcinomas. Detecting the expression of CTEN may have some significance in the prognosis of patients.