电压门控型钾通道(voltage-galed K~+ channels,Kv)是位于细胞膜上种类最多的一类钾离子通道。近些年的研究发现在许多肿瘤细胞株中Kv通道异常表达,且其活性的改变与肿瘤细胞增殖密切相关。本文对Kv通道的基本结构、类型与肿瘤的关系及可能影响肿瘤细胞增殖的机制作一综述。 Voltage-gated K ~ channels (Kv) are the most common type of potassium channel in the cell membrane. Recent studies have found that Kv channel is abnormally expressed in many tumor cell lines, and the change of its activity is closely related to tumor cell proliferation. In this paper, the basic structure of Kv channels, the relationship between the type and tumor and the mechanism that may affect the proliferation of tumor cells are reviewed.