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一个世纪前医学专家就发现女性激素尤其是雌激素可能对一些肿瘤的发生有影响。大约40年前应用雌、孕激素联合替代治疗(hormone replacement therapy,HRT)因其对围绝经期综合征及骨、心血管、脑等系统的保护作用而大为推广,甚至有人提出要终生替代。但随着一些副反应的出现,激素替代治疗的安全性又被重新反思,其中包括大量有关雌、孕激素联合替代治疗及单纯雌激素替代治疗(estro-gen replacement therapy,ERT)与肿瘤发生风险的流行病学
A century ago, medical experts found that female hormones, estrogen in particular, may have some impact on tumor development. About 40 years ago, the application of estrogen and progesterone hormone replacement therapy (HRT) was greatly promoted because of its protective effect on perimenopausal syndrome, bone, cardiovascular, brain and other systems. Some even proposed lifelong replacement . However, with the advent of some side effects, the safety of hormone replacement therapy has been re-examined, including a large number of estrogen and progestin replacement therapy and estrogen replacement therapy (estrogen replacement therapy, ERT) and the risk of cancer Epidemiology